Biohazard 4

Note: This game is also titled Biohazard 4: Wii Edition.

Completion bonuses
Successfully complete the game to unlock Professional mode, the "Extras" menu (with "Bonus", "Separate Ways", "Assignment Ada", "Mercenaries", and "Movie Browser" options), "Wii Edition credits" option (in the "Bonus" menu), Infinite Rocket Launcher, Matilda, and alternate of costumes for Ashley, Leon, and Ada.

Successfully complete the game on Professional mode to unlock the PRL 412 weapon.

Successfully complete Separate Ways mode to unlock Ashley's armored knight and Leon's suit.

Successfully complete Assignment Ada and Separate Ways mode to unlock the Chicago Typewriter weapon for purchase for one million Pesetas.

Successfully complete Mercenaries mode with all characters with a five star rank to unlock the Handcannon weapon.

Bonus characters in Mercenaries mode
Get a four star or higher rank in the indicated Mercenaries mode level to unlock the corresponding character in Mercenaries mode:

Ada Wong: Pueblo
Albert Wesker: Waterworld
Hunk: Island
Jack Krauser: Castle

Hidden videos
There are two hidden cinematics accessible at the title screen. One can be accessed by remaining idle at the main menu until it starts. The other can be seen by pressing B on the Wii-mote at the main menu.

Opening doors quicker
When the "Open" command appears by a door, tap A(2) to kick it open quickly. Doing this will also damage any enemies behind the door at the time you kick.

Easy money
To earn easy money while playing through the game again, carry an empty Handcannon. It costs no money to have, but you will pick up ammunition for it occasionally. This is worth more than any other type of ammo in the game. After collecting the ammunition, sell it to the merchant. Try using the Chicago Typewriter as your main gun while doing this.

Avoiding enemies at start
After you use the chief's false eye to open the door, walk up the hill until the truck comes at you. Shoot it and get back. Once it explodes, walk back up the hill, but go backwards. Keep going all the way to the castle and you will avoid facing the enemies that would normally appear.

Defeating the Regenerator
If you find your rifle is empty, you can also defeat the Regenerator by shooting a mine into the spot around the parasite. If it is on its back, shoot out its legs with your handgun, then fire a mine into its back. If this does not work, find out where the parasite is on the Regenerator and try again.